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apalutamide will lower the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicines which have been CYP3A4 substrates can result in lessen exposure to these remedies.DISCLAIMER The contents of the Site are fo